Hydrochloric Acid → HCID 178516746, compound

HRID 589271Notes

Reaction equation

HRID 589271 reaction equation
[C:1]1([C:7]([C:9]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)=O)=O)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Cl.[NH2:18][CH2:19][C:20]([NH2:22])=[O:21].[OH-].[Na+].Cl.C(=O)(O)[O-].[K+]>O.CO>[C:1]1([C:7]2[N:18]=[CH:19][C:20]([OH:21])=[N:22][C:9]=2[C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 8651BenzilHCID 14798Sodium HydroxideHCID 516893Potassium BicarbonateHCID 2723639Glycinamide hydrochloride

Product 1

HCID 178516746HCID 178516746, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent2×

Procedure

First, 4.2 g (20 mmol) of benzil, 2.21 g (20 mmol) of glycinamide hydrochloride, and 40 mL of methanol were put into a three-neck flask equipped with a reflux pipe, the air in the flask was replaced with nitrogen, the mixture was refluxed, an aqueous solution of 1.6 g (40 mmol) of sodium hydroxide in 3.2 mL of water was added, and the reflux was continued for 3 hours. Then, stirring was performed until the temperature of the flask was returned to room temperature. After that, 2.5 mL of 12M concentrated hydrochloric acid, 2 g of potassium bicarbonate, and 25 mL of water were added to this mixture, and filtration was performed.

Workup

  1. customequipped with a reflux pipe
  2. temperaturethe mixture was refluxed
  3. customwas returned to room temperature

Sources & evidence

ORD record
ord-8485b32618c742cda5dee371b33d11bb
Source dataset
uspto-grants-2016_01
Patent number
US09231217B2

Reaction notes

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