Hydrochloric Acid → HCID 178423975, compound

HRID 589272Notes

Reaction equation

HRID 589272 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]([C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=O)=O)=[CH:4][CH:3]=1.Cl.[NH2:20][CH2:21][C:22]([NH2:24])=[O:23].[OH-].[Na+].Cl.C(=O)(O)[O-].[K+]>O.CO>[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[N:20]=[CH:21][C:22]([OH:23])=[N:24][C:10]=2[C:12]2[CH:17]=[CH:16][C:15]([CH3:18])=[CH:14][CH:13]=2)=[CH:4][CH:3]=1

Participants

8

Reactant 5

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 769961,2-Bis(4-methylphenyl)-1,2-ethanedioneHCID 516893Potassium BicarbonateHCID 2723639Glycinamide hydrochloride

Product 1

HCID 178423975HCID 178423975, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

First, 5.5 g (23 mmol) of 4,4′-dimethylbenzil, 3.1 g (28 mmol) of glycinamide hydrochloride, 2.2 g (55 mmol) of sodium hydroxide, and 120 mL of methanol were put into a three-neck flask equipped with a reflux pipe, the air in the flask was replaced with nitrogen, and the mixture was refluxed for 8.5 hours. Then, stirring was performed until the temperature of the flask was returned to room temperature. After that, 3 mL of 12 M concentrated hydrochloric acid, 2.3 g of potassium bicarbonate, and 58 mL of water were added to this mixture, and filtration was performed.

Workup

  1. customequipped with a reflux pipe
  2. temperaturethe mixture was refluxed for 8.5 hours
  3. customwas returned to room temperature

Sources & evidence

ORD record
ord-bbc4e62e13ef41d0acf8a22fbb26a998
Source dataset
uspto-grants-2016_01
Patent number
US09231217B2

Reaction notes

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