反应详情

2-(2-Methyl-1H-indol-3-yl)acetic acid (11.7 g, 61.84 mmol) was weighed and added into 100 mL methanol. Concentrated hydrochloric acid 0.7 mL was added dropwise. It was reacted at 70° C. for 4 hours, cooled, rotate evaporated to dryness, extracted with ethyl acetate, washed twice with NaHCO3 aqueous solution. The organic phase was dried and rotate evaporated to dryness to obtain a red brown solid 11.4 g, at a yield of 90.7%.

1. customIt was reacted at 70° C. for 4 hours
2. temperaturecooled
3. customrotate evaporated to dryness
4. extractionextracted with ethyl acetate
5. washwashed twice with NaHCO3 aqueous solution
6. customThe organic phase was dried
7. customrotate evaporated to dryness