Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Toluene → HCID 178526610, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Toluene | HCID 1140 | — |
| 반응물 | 1-Ethynyl-4-nitrobenzene | HCID 136752 | — |
| 반응물 | (2-Iodophenyl)hydrazine | HCID 1381941 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Triethylamine | HCID 8471 | — |
| 생성물 | HCID 178526610 | HCID 178526610 | 19.3% |
반응 단계
Into a dry reaction vessel, 10.3 g (44 mmol) (2-iodophenyl)hydrazine, 100 mL toluene, 50 mL triethylamine, 8.41 g (57.2 mmol) p-nitro phenylacetylene, 500 mg (Ph3P)2PdCl2, 250 mg cuprous iodide were respectively added, and reacted at 110° C. under protection of nitrogen for 4.5 h. It was cooled, rotate evaporated to dryness to remove the solvent, chromatographed on a column to obtain a red liquid 2.15 g (8.50 mmol), at a yield of 19.3%.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09233098B2 |
| 출처 데이터셋 | uspto-grants-2016_01 |
| ORD ID | ord-7030a05cfa3f4956a6a8400d42f570b2 |
| 출처 메모 | uspto-grants-2016_01 |