反应详情

Into a dry reaction vessel, 10.3 g (44 mmol) (2-iodophenyl)hydrazine, 100 mL toluene, 50 mL triethylamine, 8.41 g (57.2 mmol) p-nitro phenylacetylene, 500 mg (Ph3P)2PdCl2, 250 mg cuprous iodide were respectively added, and reacted at 110° C. under protection of nitrogen for 4.5 h. It was cooled, rotate evaporated to dryness to remove the solvent, chromatographed on a column to obtain a red liquid 2.15 g (8.50 mmol), at a yield of 19.3%.

1. additionwere respectively added
2. customreacted at 110° C. under protection of nitrogen for 4.5 h
3. temperatureIt was cooled
4. customrotate evaporated to dryness
5. customto remove the solvent
6. customchromatographed on a column