反应详情

Into a dry reaction vessel, ethyl 2-[2-ethyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate (350 mg, 0.96 mmol) was added, and dissolved in 10 mL methanol. 10% Pd/C 50 mg was added, purged with dry hydrogen, and reacted for 1 h. After completion of the reaction, it was filtered, and the filter cake was washed with methanol. The filtrate was rotate evaporated to dryness to obtain a white solid 288 mg, at a yield of 89.6%.

1. additionwas added
2. custompurged with dry hydrogen
3. customreacted for 1 h
4. customAfter completion of the reaction, it
5. filtrationwas filtered
6. washthe filter cake was washed with methanol
7. customThe filtrate was rotate evaporated to dryness