ethyl 2-[2-ethyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate → ethyl 2-[3-(4-aminobenzyl)-2-ethyl-1H-indol-1-yl]acetate

Participants

Reaction Steps

Into a dry reaction vessel, ethyl 2-[2-ethyl-3-(4-nitrobenzyl)-1H-indol-1-yl]acetate (350 mg, 0.96 mmol) was added, and dissolved in 10 mL methanol. 10% Pd/C 50 mg was added, purged with dry hydrogen, and reacted for 1 h. After completion of the reaction, it was filtered, and the filter cake was washed with methanol. The filtrate was rotate evaporated to dryness to obtain a white solid 288 mg, at a yield of 89.6%.

Provenance & Evidence