Ethyl Acetate → ethyl 2-[1-(4-aminobenzyl)-1H-indazol-3-yl]acetate

Participants

Reaction Steps

Ethyl 2-[1-(4-nitrobenzyl)-1H-indazol-3-yl]acetate (340 mg, 1.04 mmol) was dissolved in methanol (20 mL). 10% Pd/C(20 mg) was added, and reacted under hydrogen atmosphere for half an hour. TLC (petroleum ether:ethyl acetate=2:1) indicated that starting material disappeared. It was filtered to remove solid, rotate evaporated to dryness to remove the solvent. The resulting solid was used for the next step directly.

Provenance & Evidence