反应详情

Ethyl 2-(1H-indazol-3-yl)acetate (9.78 g, 47.9 mmol) was dissolved in anhydrous tetrahydrofuran (100 mL). Cesium carbonate (46.81 g, 143.7 mmol) was added, and stirred at room temperature for half an hour. Then p-nitro benzyl bromide (10.36 g, 47.96 mmol) was added, reacted for 16 hours, and then the solid was filtered. The filtrate was concentrated, chromatographed on a silica gel column (petroleum ether:ethyl acetate=2:1) to obtain a yellow solid 12.68 g, at a yield of 78.1%.

1. customreacted for 16 hours
2. filtrationthe solid was filtered
3. concentrationThe filtrate was concentrated
4. customchromatographed on a silica gel column (petroleum ether:ethyl acetate=2:1)