N-bromobutanimide → HCID 90449091, compound

HRID 589401Notes

Reaction equation

HRID 589401 reaction equation
[CH3:1][C:2]1[N:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)=[O:10])=[N:6][CH:7]=1.C1C(=O)N([Br:28])C(=O)C1>C(Cl)(Cl)(Cl)Cl>[Br:28][CH2:1][C:2]1[N:3]=[CH:4][C:5]([NH:8][C:9]([C:11]2[CH:20]=[CH:19][C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[CH:12]=2)=[O:10])=[N:6][CH:7]=1

Participants

4

Reactant 2

HCID 67184N-bromobutanimideHCID 89590270HCID 89590270, compound

Product 1

HCID 90449091HCID 90449091, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

N-(5-methylpyrazin-2-yl)-2-naphthamide (2.63 g, 10.0 mmol) was weighed and dissolved in 30 mL carbon tetrachloride. NBS (1.96 g, 11.0 mmol), BPO (242 mg, 1.0 mmol) were added and heated to reflux and reacted in dark for 12 hours. It was rotate evaporated to dryness to remove the solvent, and was used for the next step directly.

Workup

  1. temperatureheated
  2. temperatureto reflux
  3. customreacted in dark for 12 hours
  4. customIt was rotate evaporated to dryness
  5. customto remove the solvent

Sources & evidence

ORD record
ord-c2f47864024942f38ba33857767249cc
Source dataset
uspto-grants-2016_01
Patent number
US09233098B2

Reaction notes

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