反应详情

Methyl 2-[1-(4-aminobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]acetate (58 mg, 0.20 mmol) and triethylamine (41 mg, 0.41 mmol) were dissolved in 15 mL dichloromethane. In an ice bath, 2-naphthoyl chloride (38 mg, 0.20 mmol) was added. Upon completion of addition, it was moved to react at room temperature for 1 hour. It was rotate evaporated to dryness to remove the solvent, and chromatographed on a column (PE:EA=15:1) to obtain a white oil 60 mg, at a yield of 65%.

1. additionUpon completion of addition, it
2. customto react at room temperature for 1 hour
3. customIt was rotate evaporated to dryness
4. customto remove the solvent
5. customchromatographed on a column (PE:EA=15:1)