HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Bicarbonate → Hydrocodone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | (4R,4aR,7aR,12bS)-9-methoxy-3-methyl-1,2,4,4a,5,6,7a,13-octahydro-4,12-methanobenzofuro[3,2-e]isoquinolin-7-one;2,3-dihydroxybutanedioic acid | HCID 20831824 | — |
| Solvent | Water | HCID 962 | — |
| Product | Hydrocodone | HCID 5284569 | — |
Reaction Steps
Hydrocodone bitartrate salt was dissolved in water. To this was added 2 equivalents solid NaHCO3. Hydrocodone precipitates and dichlormethane was added. The biphasic solution was allowed to stir for twenty minutes. The layers were then separated and the basic aqueous layer was extracted two times with dichloromethane. The organic layer was dried over MgSO4 and evaporated to yield hydrocodone free base as a white powder. Isolated yield was generally 95+%
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233168B2 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-e7182cec74e14271a01f85e0cfdb077b |
| Source note | uspto-grants-2016_01 |