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HRID589422

反应详情

EQUATION

反应方程式

HRID 589422 的结构方程式

REACTANTS

反应物

2
结构：O=C([O-])O.[Na+]
HCID516892

Sodium Bicarbonate

CHNaO3

结构：COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314.O=C(O)C(O)C(O)C(=O)O
HCID20831824

未命名化合物

PRODUCTS

生成物

1
结构：COc1ccc2c3c1O[C@H]1C(=O)CC[C@H]4[C@@H](C2)N(C)CC[C@]314
HCID5284569

Hydrocodone

C18H21NO3

AUXILIARIES

试剂、催化剂与溶剂

1
结构：O
溶剂HCID962

Water

H2O

PROCEDURE

实验过程

Hydrocodone bitartrate salt was dissolved in water. To this was added 2 equivalents solid NaHCO3. Hydrocodone precipitates and dichlormethane was added. The biphasic solution was allowed to stir for twenty minutes. The layers were then separated and the basic aqueous layer was extracted two times with dichloromethane. The organic layer was dried over MgSO4 and evaporated to yield hydrocodone free base as a white powder. Isolated yield was generally 95+%

WORKUP

后处理

  1. customHydrocodone precipitates
  2. additiondichlormethane was added
  3. customThe layers were then separated
  4. extractionthe basic aqueous layer was extracted two times with dichloromethane
  5. dry with materialThe organic layer was dried over MgSO4
  6. customevaporated