反应详情

To a solution of compound Intermediate 1 (2.60 g, 7.77 mmol) in 10 ml DCM, 30 ml TFA/water 95:5 were added. The resulting mixture was stirred at room temperature for 2 hours. The mixture was diluted with water and basified by addition of 2N sodium hydroxide and extracted with DCM. The organic layer was washed with brine (2×), dried over sodium sulfate and evaporated. The residue was purified by flash chromatography on silica (cyclohexane/EtOAc 1:1 to EtOAc) to afford the compound Intermediate 2 as a beige solid.

1. extractionextracted with DCM
2. washThe organic layer was washed with brine (2×)
3. dry with materialdried over sodium sulfate
4. customevaporated
5. customThe residue was purified by flash chromatography on silica (cyclohexane/EtOAc 1:1 to EtOAc)