Sodium Hydroxide → 4-Chloro-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine

참여 물질

역할	이름	HCID	투입량
반응물	Sodium Hydroxide	HCID 14798	—
반응물	tert-butyl 4-(4-chloro-7H-pyrrolo[2,3-d]pyrimidin-6-yl)-3,6-dihydropyridine-1(2H)-carboxylate	HCID 58709797	—
용매	Water	HCID 962	—
용매	Dichloromethane	HCID 6344	—
용매	Trifluoroacetic acid water	HCID 22392675	—
생성물	4-Chloro-6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidine	HCID 58710022	—

반응 단계

To a solution of compound Intermediate 1 (2.60 g, 7.77 mmol) in 10 ml DCM, 30 ml TFA/water 95:5 were added. The resulting mixture was stirred at room temperature for 2 hours. The mixture was diluted with water and basified by addition of 2N sodium hydroxide and extracted with DCM. The organic layer was washed with brine (2×), dried over sodium sulfate and evaporated. The residue was purified by flash chromatography on silica (cyclohexane/EtOAc 1:1 to EtOAc) to afford the compound Intermediate 2 as a beige solid.

출처 및 근거

DOI	10.6084/m9.figshare.5104873.v1
특허 번호	US09233111B2
출처 데이터셋	uspto-grants-2016_01
ORD ID	ord-1984b1a35d89477ca6d922a34658adb9
출처 메모	uspto-grants-2016_01