HRID589499

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID4400782

4-(Dimethylamino)benzoyl chloride

C9H10ClNO

HCID13767186

2-tert-Butylbenzoyl chloride

C11H13ClO

结构：Cc1c(N)cc(F)cc1-c1ncnc2[nH]c(C3=CCSCC3)cc12

HCID86730991

未命名化合物

PRODUCTS

生成物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCSCC3)cc12

HCID71230693

未命名化合物

PROCEDURE

实验过程

Example 24 was prepared analogue to Example 15 by replacing Intermediate 6 with Intermediate 16 and 4-dimethyaminobenzoyl chloride with tert-butylbenzoyl chloride.

WORKUP

后处理

customExample 24 was prepared analogue to Example 15

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-5956685ecc0749dfb006d1eeff8a1947
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

[S:1]1[CH2:6][CH:5]=[C:4]([C:7]2[NH:24][C:10]3[N:11]=[CH:12][N:13]=[C:14]([C:15]4[C:16]([CH3:23])=[C:17]([NH2:22])[CH:18]=[C:19]([F:21])[CH:20]=4)[C:9]=3[CH:8]=2)[CH2:3][CH2:2]1.CN(C)[C:27]1[CH:35]=[CH:34][C:30]([C:31](Cl)=[O:32])=[CH:29][CH:28]=1.[C:37](C1C=CC=CC=1C(Cl)=O)([CH3:40])([CH3:39])[CH3:38]>>[C:37]([C:27]1[CH:35]=[CH:34][C:30]([C:31]([NH:22][C:17]2[CH:18]=[C:19]([F:21])[CH:20]=[C:15]([C:14]3[C:9]4[CH:8]=[C:7]([C:4]5[CH2:5][CH2:6][S:1][CH2:2][CH:3]=5)[NH:24][C:10]=4[N:11]=[CH:12][N:13]=3)[C:16]=2[CH3:23])=[O:32])=[CH:29][CH:28]=1)([CH3:40])([CH3:39])[CH3:38]