HRID589502

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCC4(CC3)OCCO4)cc12

HCID71231462

未命名化合物

PRODUCTS

生成物

结构：Cc1c(NC(=O)c2ccc(C(C)(C)C)cc2)cc(F)cc1-c1ncnc2[nH]c(C3=CCC(O)CC3)cc12

HCID71230891

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

PROCEDURE

实验过程

A mixture of Example 27 (450 mg, 0.832 mmol) and TFA (6 ml) in DCM (30 ml) was stirred at r.t. for 6 hrs. The solvents were removed in vacuo and the crude product was purified by flash chromatography (silica gel, EtOAc/MeOH/NH4OH gradient) to yield Intermediate 19.

WORKUP

后处理

customThe solvents were removed in vacuo
customthe crude product was purified by flash chromatography (silica gel, EtOAc/MeOH/NH4OH gradient)

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6efca52f8599422bab2defa1e55891af
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233111B2
来源说明: uspto-grants-2016_01

反应 SMILES

[C:1]([C:5]1[CH:40]=[CH:39][C:8]([C:9]([NH:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([C:19]3[C:20]4[CH:27]=[C:26]([C:28]5[CH2:37][CH2:36][C:31]6(OCC[O:32]6)[CH2:30][CH:29]=5)[NH:25][C:21]=4[N:22]=[CH:23][N:24]=3)[C:13]=2[CH3:38])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].C(O)(C(F)(F)F)=O>C(Cl)Cl>[C:1]([C:5]1[CH:40]=[CH:39][C:8]([C:9]([NH:11][C:12]2[CH:17]=[C:16]([F:18])[CH:15]=[C:14]([C:19]3[C:20]4[CH:27]=[C:26]([C:28]5[CH2:37][CH2:36][CH:31]([OH:32])[CH2:30][CH:29]=5)[NH:25][C:21]=4[N:22]=[CH:23][N:24]=3)[C:13]=2[CH3:38])=[O:10])=[CH:7][CH:6]=1)([CH3:4])([CH3:2])[CH3:3]