反应详情

To a solution prepared by dissolving 100 mg of 5-bromofuran-2-carboxylic acid, 145 mg of (E) type 4-aminoadamantane-1-carboxylic acid amide (prepared from Preparation Example 1), and 202 mg of TBTU in MC was added dropwise 0.2 mL of DIEA and then stirred at room temperature for 4 hours. The reaction solution was washed with a 1N solution of HCl and a 1N solution of NaOH, respectively, and then washed again with brine. The resulting organic solution was dried over MgSO4 and after filtration, was distilled under a reduced pressure. The compound thus obtained was purified via recrystallization by using MeOH and ether to produce 150 mg of a white solid product.

1. customTo a solution prepared
2. washThe reaction solution was washed with a 1N solution of HCl
3. washa 1N solution of NaOH, respectively, and then washed again with brine
4. dry with materialThe resulting organic solution was dried over MgSO4
5. filtrationafter filtration
6. distillationwas distilled under a reduced pressure
7. customThe compound thus obtained
8. customwas purified via recrystallization