Phosphorus oxychloride → HCID 86689180, compound

HRID 589658Notes

Reaction equation

HRID 589658 reaction equation
[CH3:1][O:2][C:3]1[C:11]2[S:10][C:9]([S:12]([O-])(=[O:14])=[O:13])=[C:8]([CH3:16])[C:7]=2[CH:6]=[CH:5][CH:4]=1.[K+].O=P(Cl)(Cl)[Cl:20]>>[CH3:1][O:2][C:3]1[C:11]2[S:10][C:9]([S:12]([Cl:20])(=[O:14])=[O:13])=[C:8]([CH3:16])[C:7]=2[CH:6]=[CH:5][CH:4]=1

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 86689181HCID 86689181, compound

Product 1

HCID 86689180HCID 86689180, compoundYield 46%

Conditions

Temperature
60 °C

Procedure

A mixture of potassium 7-methoxy-3-methylbenzothiophene-2-sulfonate (100 mg, 0.34 mmol) in POCl3 (5 mL) was heated at 60° C. over night. The POCl3 was evaporated and the crude product was purified on a small amount of silica eluting with CH2Cl2 to give the title compound in 46% yield (43 mg).

Workup

  1. customThe POCl3 was evaporated
  2. customthe crude product was purified on a small amount of silica eluting with CH2Cl2

Sources & evidence

ORD record
ord-2ffa4cc05ebd4fab81cd77cd299eae90
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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