Phosphorus oxychloride → HCID 86689188, compound

HRID 589673Notes

Reaction equation

HRID 589673 reaction equation
[K].[CH:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([S:13](O)(=[O:15])=[O:14])=[C:10]([CH3:17])[C:9]=2[CH:18]=1)([CH3:4])[CH3:3].O=P(Cl)(Cl)[Cl:21]>>[CH:2]([C:5]1[CH:6]=[CH:7][C:8]2[O:12][C:11]([S:13]([Cl:21])(=[O:15])=[O:14])=[C:10]([CH3:17])[C:9]=2[CH:18]=1)([CH3:4])[CH3:3]

Participants

4

Reactant 3

HCID 24813Phosphorus oxychlorideHCID 5462222PotassiumHCID 86689189HCID 86689189, compound

Product 1

HCID 86689188HCID 86689188, compoundYield 33%

Conditions

Temperature
60 °C

Procedure

The potassium salt of 5-isopropyl-3-methylbenzofuran-2-sulfonic acid (100 mg, 0.34 mmol) was mixed with POCl3 (5 mL) and the reaction mixture was heated at 60° C. over night. The POCl3 was evaporated and the crude product was dissolved in CH2Cl2 and passed through a small amount of silica to give the title compound (30 mg, 33%).

Workup

  1. customThe POCl3 was evaporated
  2. dissolutionthe crude product was dissolved in CH2Cl2

Sources & evidence

ORD record
ord-35743f9b8f12490382e6491c01cccfc8
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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