3-Aminobenzoic Acid → HCID 56943086, compound

HRID 589684Notes

Reaction equation

HRID 589684 reaction equation
[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[C:9]([CH3:16])[C:8]=2[CH:17]=1)([CH3:3])[CH3:2].[NH2:18][C:19]1[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=1)[C:22]([OH:24])=[O:23]>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]2[O:11][C:10]([S:12]([NH:18][C:19]3[CH:20]=[C:21]([CH:25]=[CH:26][CH:27]=3)[C:22]([OH:24])=[O:23])(=[O:14])=[O:13])=[C:9]([CH3:16])[C:8]=2[CH:17]=1)([CH3:3])[CH3:2]

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 86689188HCID 86689188, compound2×

Product 1

HCID 56943086HCID 56943086, compoundYield 19%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-isopropyl-3-methylbenzofuran-2-sulfonyl chloride (Intermediate 16) (24 mg, 0.09 mmol) and 3-aminobenzoic acid (24 mg, 0.18 mmol) giving 6.3 mg (19%) of the title compound. MS (ESI+) calcd for C19H19NO5S 373.098393, found 373.098603.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-7e9f014cc843429292e0a30046461117
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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