3-Phenylbenzene-1-sulfonyl chloride → HCID 178527497, compound

HRID 589685Notes

Reaction equation

HRID 589685 reaction equation
[C:1]1([C:7]2[CH:8]=[C:9]([S:13](Cl)(=[O:15])=[O:14])[CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:17][C:18]1[CH:19]=[C:20]([C:24]2[NH:28][N:27]=[N:26][N:25]=2)[CH:21]=[CH:22][CH:23]=1>>[NH:28]1[C:24]([C:20]2[CH:19]=[C:18]([NH:17][S:13]([C:9]3[CH:8]=[C:7]([C:1]4[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=4)[CH:12]=[CH:11][CH:10]=3)(=[O:15])=[O:14])[CH:23]=[CH:22][CH:21]=2)=[N:25][N:26]=[N:27]1

Participants

3

Reactant 2

HCID 38027523-Phenylbenzene-1-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527497HCID 178527497, compoundYield 30.2%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 3-phenylbenzenesulfonylchloride (14 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) giving 5.7 mg (30%) of the title compound. 1H NMR (400 MHz, MeOH-d4) δ ppm 5.46-5.50 (m, 1 H) 7.24-7.43 (m, 5 H) 7.44-7.56 (m, 3 H) 7.70-7.79 (m, 4 H) 7.95-8.00 (m, 1 H). MS (ESI+) calcd for C19 H15N5O2S 377.0946, found 377.0946.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-c8ce94a7e85f43c7ae5021ac7a5245a8
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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