2,6-Dichloro-4-(trifluoromethyl)benzenesulfonyl chloride → 2,6-Dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]-4-(trifluoromethyl)benzenesulfonamide

HRID 589687Notes

Reaction equation

HRID 589687 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[S:13](Cl)(=[O:15])=[O:14].[NH2:17][C:18]1[CH:19]=[C:20]([C:24]2[NH:28][N:27]=[N:26][N:25]=2)[CH:21]=[CH:22][CH:23]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([Cl:12])[C:3]=1[S:13]([NH:17][C:18]1[CH:23]=[CH:22][CH:21]=[C:20]([C:24]2[NH:28][N:27]=[N:26][N:25]=2)[CH:19]=1)(=[O:15])=[O:14]

Participants

3

Reactant 2

HCID 27368692,6-Dichloro-4-(trifluoromethyl)benzenesulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 1785275112,6-Dichloro-N-[3-(1H-tetrazol-5-yl)phenyl]-4-(trifluoromethyl)benzenesulfonamideYield 54.8%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 2,6-dichloro-4-(trifluoromethyl)benzenesulfonyl chloride (17 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8 mg, 0.05 mmol) giving 12 mg (54%) of the title compound. MS (ESI+) calcd for C14H8Cl2F3N5O2S 436.972785, found 436.973025.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-a34b450522ba45bbbd6a0c3238f5f9b4
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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