7-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride → HCID 178432003, compound

HRID 589704Notes

Reaction equation

HRID 589704 reaction equation
[Cl:1][C:2]1[C:10]2[S:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[C:7]([CH3:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1.[NH2:16][C:17]1[CH:18]=[C:19]([C:23]2[NH:27][N:26]=[N:25][N:24]=2)[CH:20]=[CH:21][CH:22]=1>>[Cl:1][C:2]1[C:10]2[S:9][C:8]([S:11]([NH:16][C:17]3[CH:22]=[CH:21][CH:20]=[C:19]([C:23]4[NH:27][N:26]=[N:25][N:24]=4)[CH:18]=3)(=[O:13])=[O:12])=[C:7]([CH3:15])[C:6]=2[CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 587131497-Chloro-3-methylbenzo[b]thiophene-2-sulfonyl chloride2×HCID 178507542HCID 178507542, compound

Product 1

HCID 178432003HCID 178432003, compoundYield 50%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 7-chloro-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 6) (30 mg, 0.10 mmol) and 5-(3-amino-phenyl)tetrazole (34 mg, 0.21 mmol) giving 20.2 mg (50%) of the title compound. MS (ESI+) calcd for C16H12ClN5O2S2 405.012094, found 405.012294.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-3983828916254b38bed398420b12b6ba
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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