5-Methoxy-3-methylbenzo[b]thiophene-2-sulfonyl chloride → HCID 178488277, compound

HRID 589705Notes

Reaction equation

HRID 589705 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([S:11](Cl)(=[O:13])=[O:12])=[C:8]([CH3:15])[C:7]=2[CH:16]=1.[NH2:17][C:18]1[CH:19]=[C:20]([C:24]2[NH:28][N:27]=[N:26][N:25]=2)[CH:21]=[CH:22][CH:23]=1>>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]2[S:10][C:9]([S:11]([NH:17][C:18]3[CH:23]=[CH:22][CH:21]=[C:20]([C:24]4[NH:28][N:27]=[N:26][N:25]=4)[CH:19]=3)(=[O:13])=[O:12])=[C:8]([CH3:15])[C:7]=2[CH:16]=1

Participants

3

Reactant 2

HCID 574403395-Methoxy-3-methylbenzo[b]thiophene-2-sulfonyl chloride2×HCID 178507542HCID 178507542, compound

Product 1

HCID 178488277HCID 178488277, compoundYield 44.2%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting from 5-methoxy-3-methylbenzothiophene-2-sulfonyl chloride (Intermediate 8) (42 mg, 0.15 mmol) and 5-(3-amino-phenyl)tetrazole (49 mg, 0.30 mmol) giving 26.6 mg (44%) of the title compound. MS (ESI+) calcd for C17H15N5O3S2 401.061631, found 401.062391.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-f74e55260d1e4d9fb40b07cf90f7e33e
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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