4′-(Trifluoromethyl)[1,1′-biphenyl]-3-sulfonyl chloride → HCID 178527498, compound

HRID 589725Notes

Reaction equation

HRID 589725 reaction equation
[F:1][C:2]([F:20])([F:19])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]([S:15](Cl)(=[O:17])=[O:16])[CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[NH2:21][C:22]1[CH:23]=[C:24]([C:28]2[NH:32][N:31]=[N:30][N:29]=2)[CH:25]=[CH:26][CH:27]=1>>[NH:32]1[C:28]([C:24]2[CH:23]=[C:22]([NH:21][S:15]([C:11]3[CH:12]=[CH:13][CH:14]=[C:9]([C:6]4[CH:7]=[CH:8][C:3]([C:2]([F:20])([F:19])[F:1])=[CH:4][CH:5]=4)[CH:10]=3)(=[O:17])=[O:16])[CH:27]=[CH:26][CH:25]=2)=[N:29][N:30]=[N:31]1

Participants

3

Reactant 2

HCID 37893364′-(Trifluoromethyl)[1,1′-biphenyl]-3-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527498HCID 178527498, compoundYield 64.2%

Procedure

The product was synthesized according to General Procedure 1, described in Example 1, starting with {3-[4-(trifluoromethyl)phenyl]phenyl}sulfonyl chloride (17.6 mg, 0.055 mmol) and 5-(3-amino-phenyl)tetrazole (8 mg, 0.05 mmol) yielding 14.3 mg (64%) of the title compound. MS (ESI+) calcd for C20H14F3N5O2S 445.082030, found 445.081660.

Workup

  1. customThe product was synthesized

Sources & evidence

ORD record
ord-05fccb7844bb4756bda3fa76168df1cb
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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