Phenylboronic Acid → HCID 178527482, compound

HRID 589730Notes

Reaction equation

HRID 589730 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[C:22]1(B(O)O)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1>>[C:22]1([C:2]2[S:6][C:5]([S:7]([NH:10][C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]4[NH:21][N:20]=[N:19][N:18]=4)[CH:12]=3)(=[O:9])=[O:8])=[CH:4][CH:3]=2)[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Participants

3

Reactant 2

HCID 66827Phenylboronic AcidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178527482HCID 178527482, compoundYield 19.3%

Procedure

The product was prepared according to General Procedure 3, described in Example 22, starting from 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.05 mmol) and phenylboronic acid (7.3 mg, 0.06 mmol) affording 3.7 mg (19%) of the title compound. MS (ESI+) calcd for C17H13N5O2S2 383.051066, found 383.050986.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-a11d092f473f46239aa0c8bdb2a27186
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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