3-Aminobenzoic Acid → HCID 66802605, compound

HRID 589732Notes

Reaction equation

HRID 589732 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1.[NH2:16][C:17]1[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=1)[C:20]([OH:22])=[O:21]>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12]([NH:16][C:17]3[CH:18]=[C:19]([CH:23]=[CH:24][CH:25]=3)[C:20]([OH:22])=[O:21])(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1

Participants

3

Reactant 2

HCID 74193-Aminobenzoic AcidHCID 27369795-(2-methyl-1,3-thiazol-4-yl)thiophene-2-sulfonyl Chloride

Product 1

HCID 66802605HCID 66802605, compoundYield 14%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, starting with 5-(2-methylthiazol-4-yl)thiophene-2-sulfonyl chloride (15.4 mg, 0.055 mmol) and 3-aminobenzoic acid (6.9 mg, 0.05 mmol) affording 2.6 mg (14%) of the title compound. MS (ESI+) calcd for C15H21N2O4S3 379.995919, found 379.995859.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-ae77a795bba846f8b429a7989a87b72b
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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