2,4,6-Trichlorobenzenesulfonyl chloride → HCID 178527512, compound

HRID 589735Notes

Reaction equation

HRID 589735 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[S:10](Cl)(=[O:12])=[O:11].[NH2:14][C:15]1[CH:16]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:19][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[C:4]([Cl:9])[C:3]=1[S:10]([NH:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:16]=1)(=[O:12])=[O:11]

Participants

3

Reactant 2

HCID 5213352,4,6-Trichlorobenzenesulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527512HCID 178527512, compoundYield 51%

Procedure

The product was prepared according to General Procedure 6, described in Example 65, with 2,4,6-trichlorobenzenesulfonyl chloride (15.4 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 51% yield (10.7 mg). MS (ESI+) calcd mass for C13H8Cl3N5O2S 402.946428, found 402.946218.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-c7392814e1614287b4b9363ce57fdd7f
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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