3-Chloro-2-methylbenzenesulfonyl chloride → HCID 178427916, compound

HRID 589738Notes

Reaction equation

HRID 589738 reaction equation
[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8](Cl)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.[NH2:13][C:14]1[CH:15]=[C:16]([C:20]2[NH:24][N:23]=[N:22][N:21]=2)[CH:17]=[CH:18][CH:19]=1>>[Cl:1][C:2]1[C:3]([CH3:12])=[C:4]([S:8]([NH:13][C:14]2[CH:19]=[CH:18][CH:17]=[C:16]([C:20]3[NH:24][N:23]=[N:22][N:21]=3)[CH:15]=2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 5227343-Chloro-2-methylbenzenesulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178427916HCID 178427916, compoundYield 58%

Procedure

The product was prepared according to General Procedure 6, described in Example 65, with 3-chloro-2-methylbenzenesulfonyl chloride (12.4 mg, 0.055 mmol) and 5-(3-aminophenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 58% yield (10.1 mg). MS (ESI+) calcd mass for C14H12ClN5O2S 349.040023, found 349.040413.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-f741b6357e4944eb940b0b8423b03726
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

Loading…