1-Benzothiophene-2-sulfonyl chloride → HCID 178527475, compound

HRID 589751Notes

Reaction equation

HRID 589751 reaction equation
[S:1]1[C:5]2[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=2[CH:3]=[C:2]1[S:10](Cl)(=[O:12])=[O:11].[NH2:14][C:15]1[CH:16]=[C:17]([C:21]2[NH:25][N:24]=[N:23][N:22]=2)[CH:18]=[CH:19][CH:20]=1>>[NH:25]1[C:21]([C:17]2[CH:16]=[C:15]([NH:14][S:10]([C:2]3[S:1][C:5]4[CH:6]=[CH:7][CH:8]=[CH:9][C:4]=4[CH:3]=3)(=[O:12])=[O:11])[CH:20]=[CH:19][CH:18]=2)=[N:22][N:23]=[N:24]1

Participants

3

Reactant 2

HCID 27763331-Benzothiophene-2-sulfonyl chlorideHCID 178507542HCID 178507542, compound

Product 1

HCID 178527475HCID 178527475, compoundYield 60%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with 1-benzothiophene-2-sulfonyl chloride (12.8 mg, 0.055 mmol) and 5-(3-amino-phenyl)tetrazole (8.0 mg, 0.050 mmol). The title compound was obtained in 60% yield (10.8 mg). MS (ESI+) calcd mass for C15H11N5O2S2 357.035416, found 357.036256.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-8d7424a95518459c8c92aac0d6afe424
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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