Benzoic acid, 3-amino-, methyl ester → HCID 66802143, compound

HRID 589757Notes

Reaction equation

HRID 589757 reaction equation
[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12](Cl)(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1.[NH2:16][C:17]1[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=1)[C:20]([O:22][CH3:23])=[O:21]>>[CH3:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[S:11][C:10]([S:12]([NH:16][C:17]3[CH:18]=[C:19]([CH:24]=[CH:25][CH:26]=3)[C:20]([O:22][CH3:23])=[O:21])(=[O:14])=[O:13])=[CH:9][CH:8]=2)[N:6]=1

Participants

3

Reactant 2

HCID 78274Benzoic acid, 3-amino-, methyl esterHCID 27369795-(2-methyl-1,3-thiazol-4-yl)thiophene-2-sulfonyl Chloride

Product 1

HCID 66802143HCID 66802143, compound

Procedure

The title compound was prepared according to General Procedure 1, described in Example 1, with 5-(2-methylthiazol-4-yl)thiophene-2-sulphonylchloride (15.4 mg, 0.055 mmol) and methyl 3-aminobenzoate (7.6 mg, 0.050 mmol). 1H NMR (400 MHz, DMSO-d6) δ ppm 1.82-1.83 (s, 3H), 2.98-2.99 (s, 3H), 6.59-6.62 (m, 2H), 6.67-6.68 (s, 2H), 6.81-6.84 (m, 1H), 6.93-6.94 (m, 1H). MS (ESI+) m/z 395 [M+H]+.

Sources & evidence

ORD record
ord-6645a8bd67c94140a8a9406d877d9c8e
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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