Dimethyl 5-butoxyisophthalate → (3-Butoxy-5-hydroxymethyl-phenyl)-methanol

Participants

Reaction Steps

To a solution of dimethyl 5-butoxyisophthalate (0.51 g, 1.90 mmol) in THF (16 mL) was slowly added LiAlH4 (0.40 g, 10.5 mmol). The reaction mixture was stirred for 8 h. The reaction was quenched by the addition of 2N aq. HCl (5 mL). The mixture was extracted with Et2O (2×25 mL) and EtOAc (2×25 mL), the organics layers combined, dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product (0.24 g) as an oil, which was used without further purification.

Provenance & Evidence