反应详情

To a solution of dimethyl 5-butoxyisophthalate (0.51 g, 1.90 mmol) in THF (16 mL) was slowly added LiAlH4 (0.40 g, 10.5 mmol). The reaction mixture was stirred for 8 h. The reaction was quenched by the addition of 2N aq. HCl (5 mL). The mixture was extracted with Et2O (2×25 mL) and EtOAc (2×25 mL), the organics layers combined, dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product (0.24 g) as an oil, which was used without further purification.

1. customThe reaction was quenched by the addition of 2N aq. HCl (5 mL)
2. extractionThe mixture was extracted with Et2O (2×25 mL) and EtOAc (2×25 mL)
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated under reduced pressure