3,4-Dichlorobenzeneboronic acid → HCID 178527487, compound

HRID 589762Notes

Reaction equation

HRID 589762 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[Cl:22][C:23]1[CH:24]=[C:25](B(O)O)[CH:26]=[CH:27][C:28]=1[Cl:29]>>[Cl:22][C:23]1[CH:24]=[C:25]([C:2]2[S:6][C:5]([S:7]([NH:10][C:11]3[CH:16]=[CH:15][CH:14]=[C:13]([C:17]4[NH:21][N:20]=[N:19][N:18]=4)[CH:12]=3)(=[O:9])=[O:8])=[CH:4][CH:3]=2)[CH:26]=[CH:27][C:28]=1[Cl:29]

Participants

3

Reactant 2

HCID 27343303,4-Dichlorobenzeneboronic acidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178527487HCID 178527487, compoundYield 4%

Procedure

The product was prepared according to General Procedure 3, described in Example 22, using 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.055 mmol) and 3,4-dichlorophenylboronic acid (11 mg, 0.06 mmol). The title compound was obtained in 4% yield (0.8 mg). MS (ESI+) m/z 452 [M+H]+.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-d7fb0060553541f48f7412ede8b0ddff
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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