2,4-Difluorophenylboronic acid → HCID 178527488, compound

HRID 589765Notes

Reaction equation

HRID 589765 reaction equation
Br[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1.[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1B(O)O>>[F:22][C:23]1[CH:28]=[C:27]([F:29])[CH:26]=[CH:25][C:24]=1[C:2]1[S:6][C:5]([S:7]([NH:10][C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([C:17]3[NH:21][N:20]=[N:19][N:18]=3)[CH:12]=2)(=[O:9])=[O:8])=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 27343342,4-Difluorophenylboronic acidHCID 178527479HCID 178527479, compound2×

Product 1

HCID 178527488HCID 178527488, compoundYield 33%

Procedure

The product was prepared according to General Procedure 3, described in Example 22, using 5-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]thiophene-2-sulfonamide (Intermediate 17) (19 mg, 0.055 mmol) and 2,4-difluorophenylboronic acid (9 mg, 0.06 mmol). The title compound was obtained in 33% yield (6.9 mg). MS (ESI+) calcd mass for C17H11F2N5O2S2 419.032222, found 419.032372.

Workup

  1. customThe product was prepared

Sources & evidence

ORD record
ord-847abbc71acd4b609be232b76b9b9b9f
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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