5-Aminosalicylic Acid → HCID 66799893, compound

HRID 589800Notes

Reaction equation

HRID 589800 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[C:10]([S:14](Cl)(=[O:16])=[O:15])[CH:11]=[CH:12][CH:13]=2)=[CH:4][CH:3]=1.[NH2:18][C:19]1[CH:27]=[C:23]([C:24]([OH:26])=[O:25])[C:22]([OH:28])=[CH:21][CH:20]=1>>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([S:14]([NH:18][C:19]3[CH:20]=[CH:21][C:22]([OH:28])=[C:23]([CH:27]=3)[C:24]([OH:26])=[O:25])(=[O:16])=[O:15])[CH:9]=2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 40755-Aminosalicylic AcidHCID 35027603-(4-chlorophenyl)benzenesulfonyl Chloride

Product 1

HCID 66799893HCID 66799893, compoundYield 33%

Procedure

The product was prepared according to General Procedure 1, described in Example 1, with [[3-(4-chlorophenyl)phenyl]sulfonyl chloride (16 mg, 0.055 mmol) and 5-aminosalicylic acid (7.7 mg, 0.050 mmol) using a modified reaction temperature of 60° C. The title compound was obtained in 33% yield (6.7 mg). MS (ESI+) calcd mass for C19H14ClNO5S 403.028121, found 403.028561.

Workup

  1. customThe product was prepared
  2. customa modified reaction temperature of 60° C

Sources & evidence

ORD record
ord-571715aa18bf4489b09f51a222271d99
Source dataset
uspto-grants-2016_01
Patent number
US09233946B2

Reaction notes

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