HRID589900

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID105034

Isocyanate

CNO-

HCID2733380

2-Fluoro-5-(trifluoromethyl)phenyl isocyanate

C8H3F4NO

HCID118638446

未命名化合物

PRODUCTS

生成物

结构：O=C(Nc1ccc(C#Cc2ccc3nc(NC(=O)Nc4cc(C(F)(F)F)ccc4F)cn3n2)cc1)Nc1cc(C(F)(F)F)ccc1F

HCID118638421

未命名化合物

PROCEDURE

实验过程

The compound of Example 10 was made by preparing 6-[(4-aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine as in Example 20, followed by a procedure similar to Example 3 using 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene as the isocyanate (see also Schemes 1, 2, and 9).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-aa66ad06f54d44cf88a1d004678b1a8f
来源数据集: uspto-grants-2016_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09233968B1
来源说明: uspto-grants-2016_01

反应 SMILES

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]3[N:14]([CH:16]=[C:17]([NH2:19])[N:18]=3)[N:15]=2)=[CH:4][CH:3]=1.[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[N:31]=[C:32]=[O:33].[N-:34]=[C:35]=[O:36]>>[F:20][C:21]1[CH:26]=[CH:25][C:24]([C:27]([F:30])([F:29])[F:28])=[CH:23][C:22]=1[NH:31][C:32]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]#[C:9][C:10]2[CH:11]=[CH:12][C:13]3[N:14]([CH:16]=[C:17]([NH:19][C:35]([NH:34][C:22]4[CH:23]=[C:24]([C:27]([F:29])([F:30])[F:28])[CH:25]=[CH:26][C:21]=4[F:20])=[O:36])[N:18]=3)[N:15]=2)=[CH:4][CH:3]=1)=[O:33]