Isocyanate → 1-[2-Fluoro-5-(trifluoromethyl)phenyl]-3-[4-({2-[({[2-fluoro-5-(trifluoromethyl)phenyl]amino}carbonyl)amino]imidazo[1,2-b]pyridazin-6-yl}ethynyl)phenyl]urea

Participants

Reaction Steps

The compound of Example 10 was made by preparing 6-[(4-aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine as in Example 20, followed by a procedure similar to Example 3 using 1-fluoro-2-isocyanato-4-(trifluoromethyl)benzene as the isocyanate (see also Schemes 1, 2, and 9).

Provenance & Evidence