HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isocyanate → 1-{6-[(4-Aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-yl}-3-(3-chloro-4-fluorophenyl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isocyanate | HCID 105034 | — |
| Reactant | 3-Chloro-4-fluorophenyl isocyanate | HCID 2734632 | — |
| Reactant | 6-[(4-Aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine | HCID 118638446 | — |
| Product | 1-{6-[(4-Aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-yl}-3-(3-chloro-4-fluorophenyl)urea | HCID 118638410 | — |
Reaction Steps
The compound of Example 14 was made by preparing 6-[(4-aminophenyl)ethynyl]imidazo[1,2-b]pyridazin-2-amine as in Example 20, followed by a procedure similar to Example 3 using 2-chloro-1-fluoro-4-isocyanatobenzene as the isocyanate (see also Schemes 1, 2, and 9).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09233968B1 |
| Source dataset | uspto-grants-2016_01 |
| ORD ID | ord-92a16ca88f5f4c25b00539c82596d582 |
| Source note | uspto-grants-2016_01 |