Hydrochloric Acid → 2-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride

HRID 589917Notes

Reaction equation

HRID 589917 reaction equation
C(OC([N:8]1[CH2:13][CH:12]([CH3:14])[N:11]([C:15]2[N:20]=[CH:19][CH:18]=[CH:17][N:16]=2)[CH:10]([CH3:21])[CH2:9]1)=O)(C)(C)C.[ClH:22]>C(O)C>[ClH:22].[CH3:21][CH:10]1[CH2:9][NH:8][CH2:13][CH:12]([CH3:14])[N:11]1[C:15]1[N:16]=[CH:17][CH:18]=[CH:19][N:20]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 594069863,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester

Product 1

HCID 684321412-(2,6-Dimethylpiperazin-1-yl)pyrimidine hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3,5-Dimethyl-4-pyrimidin-2-ylpiperazine-1-carboxylic acid tert-butyl ester (294 mg) was dissolved in ethanol (2 ml), 4N hydrochloric acid (ethyl acetate solution, 2 ml) was added and the mixture was stirred at room temperature for 4 hr. The solvent was evaporated, and ethyl acetate (3 ml) was added to the obtained residue. The solid insoluble in ethyl acetate was collected by filtration and dried to give the title compound (281 mg).

Workup

  1. customThe solvent was evaporated
  2. additionethyl acetate (3 ml) was added to the obtained residue
  3. filtrationThe solid insoluble in ethyl acetate was collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-014cdd280ff74bbc90231b19d4f3dd78
Source dataset
uspto-grants-2016_01
Patent number
US09233969B2

Reaction notes

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