Aluminium lithium hydride → HCID 117704465, compound

HRID 58992Notes

Reaction equation

HRID 58992 reaction equation
[CH2:1]([CH:3]([CH2:20][CH3:21])[CH2:4][O:5][C:6]1[CH:7]=[C:8]([C:16](OC)=[O:17])[CH:9]=[C:10]([CH:15]=1)[C:11](OC)=[O:12])[CH3:2].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[CH2:20]([CH:3]([CH2:1][CH3:2])[CH2:4][O:5][C:6]1[CH:15]=[C:10]([CH2:11][OH:12])[CH:9]=[C:8]([CH2:16][OH:17])[CH:7]=1)[CH3:21]

Participants

4

Reactant 2

HCID 21226445Aluminium lithium hydrideHCID 117704493Dimethyl 5-(2-ethylbutoxyl)isophthalate

Product 1

HCID 117704465HCID 117704465, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a solution of dimethyl 5-(2-ethylbutoxyl)isophthalate (0.62 g, 2.10 mmol) in THF (20 mL) was added LiAlH4 (0.24 g, 6.32 mmol). The reaction mixture was stirred for 8 h and subsequently quenched with 2N HCl (10 mL) and extracted with Et2O (2×25 mL) and EtOAc (2×25 mL). The combined organics were dried over Na2SO4, filtered, and concentrated under reduced pressure to afford the desired product which was used without further purification.

Workup

  1. customsubsequently quenched with 2N HCl (10 mL)
  2. extractionextracted with Et2O (2×25 mL) and EtOAc (2×25 mL)
  3. dry with materialThe combined organics were dried over Na2SO4
  4. filtrationfiltered
  5. concentrationconcentrated under reduced pressure

Sources & evidence

ORD record
ord-58e4055e7e0b4beeaf5660b75a50ed92
Source dataset
uspto-grants-2016_09
Patent number
US09439433B2

Reaction notes

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