Acetonitrile → THF tetrahydrofurane

HRID 589942Notes

Reaction equation

HRID 589942 reaction equation
[C:1]([O-:4])(=[O:3])[CH3:2].[NH4+].[CH3:6][C:7]#N>>[CH2:2]1[CH2:1][O:4][CH2:7][CH2:6]1.[O:3]1[CH2:7][CH2:6][CH2:2][CH2:1]1

Participants

3

Reactant 2

HCID 6342AcetonitrileHCID 517165Ammonium Acetate

Product 1

HCID 22180045THF tetrahydrofurane

Procedure

Analytical HPLC/MS Analytical HPLC/MS was performed on a system consisting of a Waters Acquity UPLC, Waters Micromass LCT Premier XE mass spectrometer, Waters Acquity PDA. Column: Acquity UPLC HSS T3 1.8 μm; 2.1×50 mm; solventsystem: A=10 mM Ammonium acetate+0.1% HCOOH and B═CH3CN+0.1% HCOOH; flow rate=0.7 mL/min; method (4.8 min): Linear gradient method going from 1% B to 95% B in 2.6 minutes and staying at 95% B for 1.2 minute. General Procedure of Preparation:

Workup

  1. waitstaying at 95% B for 1.2 minute
  2. customGeneral Procedure of Preparation

Sources & evidence

ORD record
ord-b641a074d09f43238065f64440339857
Source dataset
uspto-grants-2016_01
Patent number
US09233964B2

Reaction notes

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