反应详情

To 4-(4,7-diaza-spiro[2.5]oct-7-yl)-7H-pyrrolo[2,3-d]pyrimidine (1 g, 4.4 mmol) (intermediate 21) in dry dioxane (20 mL) was added sulfamide (419 mg, 4.4 mmol). The reaction mixture was heated to reflux for 6 hours. After evaporation of the solvent in vacuo the crude mixture was purified by flash chromatography on silica using heptane→EtOAc:MeOH (9:1) as eluent.

1. temperatureThe reaction mixture was heated
2. temperatureto reflux for 6 hours
3. customAfter evaporation of the solvent in vacuo the crude mixture
4. customwas purified by flash chromatography on silica