反应详情

2-Benzylidene-3-cyclohexylamino-indan-1-one (3, BCI) (317 mg, 1 mmol) was dissolved in dry THF (15 mL) under nitrogen. Solution of LiAlH4 (76 mg, 2 mmol) in dry THF (10 mL) was added dropwise at 0° C. Solution was stirred overnight and quenched with 100 μL of water followed by 100 μL of 15% NaOH followed by 300 μL of water. Precipitate was filtered off and washed with ether (3×30 mL). Combined liquid was evaporated in vacuum, and residue was separated by column chromatography on silica (DCM-MeOH—NH4OH 100:1:0.5).

1. customquenched with 100 μL of water
2. filtrationPrecipitate was filtered off
3. washwashed with ether (3×30 mL)
4. customwas evaporated in vacuum, and residue
5. customwas separated by column chromatography on silica (DCM-MeOH—NH4OH 100:1:0.5)