反应详情

A solution of tert-butyl 2-fluoro-4-(3-methyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yloxy)phenylcarbamate (2.18 g, 5.8 mmol) in 1 M TBAF in THF (41 mL) was refluxed overnight under an argon atmosphere. The solution was cooled and evaporated and water (20 mL) was added, upon which a precipitate formed. The precipitate was filtered, washed with water, and dried to give the title compound as an off-white solid.

1. temperatureThe solution was cooled
2. customevaporated
3. additionwater (20 mL) was added, upon which a precipitate
4. customformed
5. filtrationThe precipitate was filtered
6. washwashed with water
7. customdried