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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 590435Generated: October 30, 2026

1,4-Dibromobutane → 2-(Butyloxy)-8-(methyloxy)-9-[4-(1-pyrrolidinyl)butyl]-9H-purin-6-amine formic acid salt

https://huagongshe.com/reaction/590435

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,4-DibromobutaneHCID 8056—
ReactantPyrrolidineHCID 31268—
Reactant9-[3-(1-Azetidinyl)propyl]-2-(butyloxy)-8-(methyloxy)-9H-purin-6-amineHCID 59252600—
ReactantHCID 178450357HCID 178450357—
Product2-(Butyloxy)-8-(methyloxy)-9-[4-(1-pyrrolidinyl)butyl]-9H-purin-6-amine formic acid saltHCID 66726984—

Reaction Steps

Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and pyrrolidine but with mass directed autopreparation using Method D.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS09233962B2
Source datasetuspto-grants-2016_01
ORD IDord-07ef2c7f12fd4d0798d01cb2753483a0
Source noteuspto-grants-2016_01