1,4-Dibromobutane → 2-(Butyloxy)-8-(methyloxy)-9-[4-(1-pyrrolidinyl)butyl]-9H-purin-6-amine formic acid salt
Reaction equation
N1([CH2:5][CH2:6][CH2:7][N:8]2[C:16]([O:17][CH3:18])=[N:15][C:14]3[C:9]2=[N:10][C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[N:12][C:13]=3[NH2:19])CCC1.F[C:26](F)(F)[C:27]([OH:29])=[O:28].C(OC1N[C:39](N)=[C:40]2[C:44](N=1)=[N:43][C:42](OC)=N2)CCC.BrCCCCBr.N1CCCC1>>[CH:27]([OH:29])=[O:28].[CH2:21]([O:20][C:11]1[N:10]=[C:9]2[C:14]([N:15]=[C:16]([O:17][CH3:18])[N:8]2[CH2:7][CH2:6][CH2:5][CH2:26][N:43]2[CH2:42][CH2:39][CH2:40][CH2:44]2)=[C:13]([NH2:19])[N:12]=1)[CH2:22][CH2:23][CH3:24]Participants
5
Procedure
Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and pyrrolidine but with mass directed autopreparation using Method D.
Sources & evidence
- ORD record
- ord-07ef2c7f12fd4d0798d01cb2753483a0
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233962B2
Reaction notes
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