1,4-Dibromobutane → 2-(Butyloxy)-9-[4-(hexahydro-1H-azepin-yl)butyl]-8-(methyloxy)-9H-purin-6-amine
Reaction equation
N1([CH2:5][CH2:6][CH2:7][N:8]2[C:16]([O:17][CH3:18])=[N:15][C:14]3[C:9]2=[N:10][C:11]([O:20][CH2:21][CH2:22][CH2:23][CH3:24])=[N:12][C:13]=3[NH2:19])CCC1.F[C:26](F)(F)[C:27](O)=O.C(OC1NC(N)=C2C(N=1)=NC(OC)=N2)CCC.BrCCCCBr.[NH:55]1[CH2:61]C[CH2:59][CH2:58][CH2:57][CH2:56]1>>[CH2:21]([O:20][C:11]1[N:10]=[C:9]2[C:14]([N:15]=[C:16]([O:17][CH3:18])[N:8]2[CH2:7][CH2:6][CH2:5][CH2:61][N:55]2[CH2:27][CH2:26][CH2:59][CH2:58][CH2:57][CH2:56]2)=[C:13]([NH2:19])[N:12]=1)[CH2:22][CH2:23][CH3:24]Participants
5
Procedure
Prepared similarly to Intermediate 20 from 2-(butyloxy)-8-(methyloxy)-1H-purin-6-amine trifluoroacetate, 1,4-dibromobutane and hexahydro-1H-azepine.
Sources & evidence
- ORD record
- ord-cc7644b051894ffeaa1c0696b985ae9e
- Source dataset
- uspto-grants-2016_01
- Patent number
- US09233962B2
Reaction notes
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