Trifluoroacetic acid → HCID 178494005, compound

HRID 590469Notes

Reaction equation

HRID 590469 reaction equation
[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([O:12][C:13]2[N:21]=[C:20]3[C:16]([N:17]=[C:18]([O:28][CH3:29])[N:19]3C3CCCCO3)=[C:15]([NH2:30])[N:14]=2)[CH2:11][CH2:10][CH2:9]1>CO>[F:1][C:2]([F:7])([F:6])[C:3]([OH:5])=[O:4].[CH:8]1([O:12][C:13]2[NH:14][C:15]([NH2:30])=[C:16]3[C:20]([N:21]=2)=[N:19][C:18]([O:28][CH3:29])=[N:17]3)[CH2:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 592526012-(Cyclobutyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine

Product 1

HCID 178494005HCID 178494005, compoundYield 78.6%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
20 °C

Procedure

Trifluoroacetic acid (3 ml, 38.9 mmol) was added to a solution of 2-(cyclobutyloxy)-8-(methyloxy)-9-(tetrahydro-2H-pyran-2-yl)-9H-purin-6-amine (1.27 g, 3.98 mmol) in methanol (50 ml) and the mixture stirred at 20° C. under an atmosphere of nitrogen for 21 hours. The solvent was removed in vacuo, and the residual solid was triturated with 1,1-dimethylethyl methyl ether and then collected by filtration and dried in vacuo to give the title compound as a cream solid (1.0922 g).

Workup

  1. customThe solvent was removed in vacuo
  2. customthe residual solid was triturated with 1,1-dimethylethyl methyl ether
  3. filtrationcollected by filtration
  4. customdried in vacuo

Sources & evidence

ORD record
ord-0d6a8ec226ac4ed9bef5a75b9b185b6a
Source dataset
uspto-grants-2016_01
Patent number
US09233962B2

Reaction notes

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